Kuma daminɛcogo bɛɛ lajɛlen
3,4-Dihydro-2H-pyran (DHP, CAS 110-87-2) ye cɛmancɛ ni fɛn ye min nafa ka bon kosɛbɛ fɛnɲɛnamaw dilanni na, kɛrɛnkɛrɛnnenya la, a dɔnna a jɔyɔrɔ la dɔlɔ lakananifɛn ye. I n’a fɔ etɛri cyclique unsaturated min ye mɔgɔ wɔɔrɔ ye, DHP bɛ tetarahidropiranili (THP) ɛtiriw dilan ni a ni dɔlɔw bɛ ɲɔgɔn sɔrɔ asidi cogoyaw la. Nin lakanani fɛɛrɛ in nafa ka bon kosɛbɛ senna-tɛgɛrɛ caman kɛli la walasa ka farikoloɲɛnajɛw bali minnu man ɲi hidrɔkisili yɔrɔw la ka sɔrɔ ka bɛnkan sabati ni fɛnɲɛnamafagalan jɔnjɔnw ni nukilifiliw ye.
DHP ye ji ye min tɛ kulɛri sɔrɔ, a tobilen ka dɔgɔn, min bɛ sɔrɔ dihidropiran walima furfural kura sɔrɔli fɛ. A ka vinyl éther structure reactive bɛ se ka kɛ sababu ye ka fɛn dɔw sɛmɛntiya sugandilenw na ani ka fɛnw caman tigɛli kɔlɔsi, o min b’a to a nafa ka bon bi sintetiki chimie laboratuwariw la ani furakɛli R&D pipelines kɔnɔ.
Fɛn dilannenw kunnafoni
| Fɛn dilannen Tɔgɔ | DHP ka sitɛzi organique CAS 110-87-2 |
| CAS NO. | 110-87-2 |
| Kɔrɔɲɔgɔnmaw | DHP ye |
| Formula Moleculaire (Fɔmula molekilɛri). | C5H8O |
| HS Kode ye | 2932999099 |
| Formula structurelle (Formule structurel) ye |  |
Kɛrɛnkɛrɛnnenya la
|
Minɛns |
Sariya |
|
Yecogo |
Ji jɛlen min tɛ kulɛri ye |
|
Saniya (%) . |
A ka bon walima a bɛ bɛn 98,5 ma |
|
Bugun (%) |
A ka dɔgɔn walima a bɛ bɛn 0,25 ma |
|
THP(%) 1.1. |
1,3 max |
| Density (g/cm3) . | 0.922 |
Baarakɛcogo & Baarakɛcogo koloma min bɛ kɛ ni fɛnɲɛnamaw ka sɛnɛfɛnw ye
- THP Ether Formation (Dɔlɔ lakanani):
DHP bɛ ɲɔgɔn sɔrɔ ni alikɔli fɔlɔ ni filanan ye asidi katalisita (misali la, p-TsOH, HCl) ɲɛkɔrɔ walasa ka THP ɛtiriw dilan. Olu bɛ hidroksili kuluw tanga oksidan, asilisi walima alkilili ma taabolo nataw la.
- Deprotection (Lakanali) sugandilen:
THP kuluw bɛ bɔ nɔgɔya la ni asidi nɔgɔman ye (misali la, asidi asetiki ji la walima TFA), o bɛ orthogonality ɲuman di kuluw lakanani fɛɛrɛw la.
- A kɛcogo minnu bɛ Kɛ ni Molecules Complex Synthèse ye:
Fɛn minnu bɛ sɔrɔ sigida la:THP etɛriw bɛ baarakɛminɛn caman cɛmancɛw sabati.
Pepitidi ni witaminiw:Idroksili-kɔnɔna cakɛdaw ni sukaro dɔlɔw lakanani sugandilen.
API sinsinni: 1.1.A bɛ kɛ furaw la i n’a fɔ eritoromisini, stɛroyidi, ani alkaloyi.
- Nafa minnu bɛ sabatili la:
THP etɛriw bɛ sabati basigi, dɔgɔyali ani oksidan nɔgɔmanw na, o bɛ sira di walew ma i n’a fɔ Grignard farali, basi-promoted condensations, ani metal-catalyzed couplings.
Fɛn dilanni Seko ni dɔnko
Dafalenw-Sikili Lakanali Seereyaw
Sintezi organique baarakɛcogo minnu bɛ fɔ
Dɔlɔw lakanani fɛɛrɛ caman -sɛnɛfɛnw nafamafɛnw bɛɛ lajɛlen na
THP etɛriw sɔrɔli witaminiw ka chimie la
Pepitidi sɔrɔli min bɛ kɛ ni serini, treyonini ani tirosini lakanani ye
Grignard ni organolithium chimie min bɛ kɛ ni hydroxyl-ni precurseurs ye
Fura cɛmancɛw dilanni yɔrɔ min na hidroksili masiki nafa ka bon kosɛbɛ
Paki kɛli
A bɛ sɔrɔ: dunun kilo 180, galasi buteli 1L walima 5L minnu bɛ kɛ laboratuwari la
Ɲininkaliw
J: Mun na DHP ka fisa dɔlɔw lakanani na?
A: A bɛ kɛ cogo nɔgɔman na, a bɛ sabatili ɲuman di THP etɛriw ma cogo basigilen walima cogoya neutre la, wa a bɛ bɔ nɔgɔya la ni a b’a fɛ.
J: Yala DHP bɛnnen don otomatiki sintezi baarakɛcogo ma wa?
A: Ɔwɔ. A kɛcogo min bɛ se ka fɔ ka ɲɛ ani a bɛnkan ni lakanani sariyalenw-deprotection protocoles ye, o b’a to a ka ɲi kosɛbɛ otomatiki ni baarakɛcogo caman na.
J: Yala DHP bɛ se ka baara kɛ ni scale-up processus ye wa?
A: Tiɲɛ don. DHP bɛ sɔrɔ caman na, wa a bɛ kɛ kilo-ka se-tɔn na furakɛli ni kemikɛli ɲumanw na.
Kɛrɛnkɛrɛnnenya la
|
Minɛns |
Sariya |
|
Yecogo |
Ji jɛlen min tɛ kulɛri ye |
|
Saniya (%) . |
A ka bon walima a bɛ bɛn 98,5 ma |
|
Bugun (%) |
A ka dɔgɔn walima a bɛ bɛn 0,25 ma |
|
THP(%) 1.1. |
1,3 max |
| Density (g/cm3) . | 0.922 |
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